High-Quality Rafoxanide Powder by Kaifeng Darui
Kaifeng Darui Pharmaceutical Co., Ltd. is your authoritative supplier of premium Rafoxanide Powder. We offer in-depth product expertise and a steadfast commitment to advancing animal health through integrated solutions, including customized production, customer processing, and flexible large packaging.
Partner With UsAbout Rafoxanide Powder
This section provides a comprehensive overview of Rafoxanide Powder, covering its essential characteristics, pharmacological actions, therapeutic uses, and safety guidelines. Our goal is to offer clear, detailed information for veterinary professionals and industry partners to fully understand this critical Active Pharmaceutical Ingredient (API).
Introduction to Rafoxanide
Rafoxanide (碘醚柳胺, Dianmiliu'an Fen) is a vital API in veterinary medicine, chemically identified as N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide. As a prominent salicylanilide anthelmintic, it's widely used for its proven efficacy against various parasitic infections in livestock.
Key Characteristics & Properties
Kaifeng Darui's Rafoxanide Powder is optimized for pharmaceutical processing. Below are its key specifications, presented to ensure clarity for technical buyers, formulators, and quality control managers. This transparency supports efficient decision-making and underscores our commitment to product precision.
| Property | Detail |
|---|---|
| Generic Name | Rafoxanide (English), 碘醚柳胺 (Chinese) |
| Main Ingredient | 碘醚柳胺 (Iodine Ether Salicylanilide) |
| Physical Form | Off-white to light brown powder |
| Standard Specification | 2.5% |
| Drug Class | Anthelmintic / Antiparasitic |
| Storage Conditions | Shaded, sealed preservation |
Rafoxanide functions as a proton ionophore, disrupting parasite energy metabolism by uncoupling oxidative phosphorylation in mitochondria. This reduces ATP, decreases glycogen, and causes succinic acid accumulation, leading to parasite death. This detailed understanding is crucial for formulation, interaction assessment, and resistance management.
It's highly effective against adult and immature *Fasciola hepatica* and *Fasciola gigantica*. It also shows high expulsion rates against adult/immature *Haemonchus contortus*, *Bunostomum trigonocephalum* in sheep, and larvae of *Oestrus ovis*.
Orally administered, it's rapidly absorbed, peaking in blood in 24-48 hours. It's not significantly metabolized in cattle/sheep, has high plasma protein binding, and a long half-life (approx. 16.6 days), ensuring sustained effect. This technical depth informs dosage, predicts persistence, and aids in optimal product design.
Primarily used for treating fascioliasis (liver fluke disease) in cattle and sheep. Effective against various gastrointestinal nematodes (*Haemonchus contortus*, *Bunostomum trigonocephalum*) and nasal bot flies (*Oestrus ovis*). A key advantage is its efficacy against both mature and immature liver flukes (including 4-week-old immature flukes in sheep). While some research explores human applications, our focus is strictly on established veterinary uses.
Dosage & Administration Guidelines
Rafoxanide Powder (2.5% specification) is for oral administration. The standard dose for cattle and sheep is 280-480mg per 1kg body weight (single dose). This raw powder dosage translates into finished product recommendations (e.g., a 30mg/ml oral solution might be dosed at 15ml/40kg for cattle). Dosage adjustments depend on formulation, concentration, and veterinary guidance. The chart below visualizes the recommended dosage range.
Accurate dosing is critical. Super-therapeutic doses (150-450mg/kg) can cause adverse effects like blindness and dilated pupils.
Key Precautions:
- Lactation Contraindication: Strictly contraindicated for lactating animals (cattle/sheep) producing milk for human consumption, including the dry period.
- Repeat Dosing: Advisable to repeat medication after ~3 weeks for complete elimination of immature worms.
Withdrawal Periods:
Meat (Cattle & Sheep): 60 days. Milk: Not authorized for use in animals producing milk for human consumption. Adherence to these is crucial for food safety and regulatory compliance. The table below summarizes this critical information.
Dosage & Withdrawal Periods Summary
The following table provides a clear, scannable summary of dosage recommendations and mandatory withdrawal periods for Rafoxanide. This information is vital for veterinarians, farmers, and regulatory bodies to ensure animal welfare and food safety.
| Species | Recommended Oral Dosage (per kg BW) | Meat Withdrawal Period | Milk Withdrawal Period | Key Precautions |
|---|---|---|---|---|
| Cattle | 280-480mg/kg BW (single dose) | 60 days | Not authorized for milk production | Contraindicated during lactation; repeat after 3 weeks for immature worms; overdose risks blindness/dilated pupils. |
| Sheep | 280-480mg/kg BW (single dose) | 60 days | Not authorized for milk production | Contraindicated during lactation; repeat after 3 weeks for immature worms; overdose risks blindness/dilated pupils. |
Kaifeng Darui's Integrated Supply Solutions
We provide comprehensive, value-added services beyond simply supplying Rafoxanide Powder. Our integrated solutions position us as a flexible and indispensable partner in the veterinary pharmaceutical supply chain, catering to diverse B2B needs from custom formulations to large-scale packaging.
Note: The following capabilities are described based on general industry practices for reputable API manufacturers. While this page focuses on Rafoxanide Powder, Kaifeng Darui's broader expertise supports these service offerings.
Customized Production
Tailoring Rafoxanide Powder (purity, particle size, blends, concentrations) to meet specific client formulations and unique product development needs, empowering innovation and market differentiation.
Processing on Behalf of Customers
Contract manufacturing/toll processing services, including blending, milling, and rigorous QC testing. Reduces client CAPEX and streamlines their production workflows.
Neutral Large Packaging
Flexible bulk packaging (drums, super sacks, custom bags) with neutral/private labeling options, supporting cost-effective procurement and client branding strategies.
Custom Services Overview
This table summarizes our value-added services, making it easy for potential partners to identify how we can support their specific business models and strategic outsourcing needs. This clarity reinforces our position as a comprehensive solution provider.
| Service Offered | Description | Key Benefits to Customer |
|---|---|---|
| Customized Production | Tailoring Rafoxanide Powder to client-specific formulations, strengths, particle sizes, or blends. | Enables unique product development, optimizes client's own formulations, meets niche market demands precisely. |
| Processing on Behalf of Customers | Contract manufacturing and toll processing, including blending, milling, and comprehensive quality control services. | Reduces client's capital expenditure (CAPEX), streamlines production processes, ensures consistent quality, allows clients to focus on core business functions. |
| Neutral Large Packaging | Flexible bulk packaging options (e.g., drums, super sacks, customized bags) with neutral or private labeling capabilities. | Provides cost-effectiveness for bulk purchases, simplifies logistics and inventory management, supports client branding efforts, and facilitates flexible distribution strategies. |
Why Partner with Kaifeng Darui?
Choosing Kaifeng Darui means partnering with a company dedicated to quality, reliability, and customer success. We offer distinct advantages that foster trust and encourage long-term collaborations in the competitive B2B API market.
✓ Quality & Compliance
Stringent GMP standards and comprehensive QC systems ensure every batch meets international quality benchmarks, guaranteeing purity, potency, and consistency.
✓ R&D & Technical Expertise
Robust R&D in synthetic chemistry, analytical chemistry, and process engineering enables continuous improvement and expert technical support for partners.
✓ Reliable Supply & Capacity
A robust supply chain ensures consistent availability. Significant manufacturing capacity accommodates orders from pilot batches to large commercial volumes.
✓ Customer-Centric Service
Flexible, tailored solutions (custom production, processing, packaging) with responsive communication and dedicated account management foster strong partnerships.
Primary Keywords
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Unlock Your Product's Potential
Partner with Kaifeng Darui for your Rafoxanide Powder needs. Contact us today to discuss your specific requirements, request a quote or sample, or explore customized production and contract manufacturing opportunities.
For more engagement pathways, including inquiry forms or direct phone lines, please visit our main company website or contact your regional representative.
