Introduction to Aminopyrine CAS 58-15-1
Aminopyrine, identified by its CAS number 58-15-1, is a pyrazolone derivative with significant historical and pharmaceutical importance. Known for its analgesic, antipyretic, and anti-inflammatory properties, this compound has been utilized in various medical applications, though its use is now restricted in many regions due to safety concerns. Kaifeng Darui Pharmaceutical Co., Ltd., a leading manufacturer in China, produces high-quality Aminopyrine, adhering to stringent quality standards. This article delves into the chemical properties, applications, safety considerations, and the pivotal role of Kaifeng Darui in supplying this compound to the global market.
Chemical Profile of Aminopyrine
Aminopyrine, also known as Aminophenazone, Amidopyrine, or 4-Dimethylaminoantipyrine, is a white or almost white crystalline powder with a molecular formula of C13H17N3O and a molecular weight of 231.29. Its chemical structure features a pyrazolone core substituted with a dimethylamino group at position 4, methyl groups at positions 1 and 5, and a phenyl group at position 2. Key physical and chemical properties include:
- Melting Point: 107–109°C
- Solubility: Soluble in ethanol, chloroform, benzene, and ether; moderately soluble in water, with increased solubility in the presence of sodium benzoate.
- Appearance: Odorless, slightly bitter crystalline powder, stable in air but sensitive to sunlight and moisture.
- Reactivity: Can react with weak oxidants in the presence of moisture, requiring storage in a cool, dry, and dark environment.
Aminopyrine’s chemical stability and solubility make it a versatile compound for pharmaceutical formulations, though its use requires careful handling due to potential interactions with other substances.
Pharmacological Applications
Aminopyrine belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and is known for its ability to alleviate pain, reduce fever, and combat inflammation. Its mechanism of action involves inhibiting the synthesis and release of prostaglandin E1 in the hypothalamus, which helps regulate body temperature and reduce fever. Additionally, it stabilizes lysosomal membranes and influences phagocytosis, contributing to its anti-inflammatory effects. Historically, Aminopyrine was used to treat conditions such as:
- Headaches and migraines
- Rheumatoid arthritis
- Fever associated with infections
- General pain relief
However, due to its association with agranulocytosis—a severe reduction in white blood cells—its therapeutic use has been largely discontinued in many countries, including the United States, where the FDA withdrew it from the market in 2000. Today, its primary applications are in research and as a reference standard in analytical chemistry.
Synthesis and Manufacturing Process
The synthesis of Aminopyrine involves the alkylation of 4-Aminoantipyrine via catalytic hydrogenation. The process, as outlined by industry standards, includes the following steps:
- Dissolve 4-Aminoantipyrine in water at 50–60°C with stirring.
- Transfer the solution to a hydrogenation tank with a nickel catalyst.
- Introduce hydrogen under controlled pressure (0.245 MPa) and add formaldehyde to facilitate the reaction.
- Maintain the reaction temperature between 60–85°C, monitoring hydrogen absorption.
- Filter the resulting crude Aminopyrine, cool the filtrate to below 25°C, and crystallize.
- Refine the crude product with ethanol and activated carbon, heating to 75–80°C, then cooling to 10°C for final crystallization.
- Filter, wash with ethanol, and air-dry to obtain pure Aminopyrine.
Kaifeng Darui Pharmaceutical Co., Ltd. employs advanced manufacturing techniques to ensure the purity of Aminopyrine exceeds 98%, meeting standards such as WS1-111-83-89 and BPC54. Their state-of-the-art facilities and rigorous quality control make them a trusted supplier in the global pharmaceutical market.
Safety and Regulatory Considerations
While Aminopyrine is effective, its use is associated with significant safety risks, notably agranulocytosis, which can be life-threatening. Research suggests that the oxidation of Aminopyrine by hypochlorite can form a reactive dication, potentially contributing to this adverse effect. Other side effects include allergic reactions, gastrointestinal bleeding, liver and kidney damage, and irritability, particularly with long-term exposure. Due to these risks, Aminopyrine is classified as a toxic substance (UN 2811 6.1 PG 3) and is banned in many countries for therapeutic use.
Kaifeng Darui provides comprehensive Material Safety Data Sheets (MSDS) with each batch, detailing handling, storage, and disposal guidelines. The company recommends storing Aminopyrine in tightly sealed containers in a cool, dry, and dark location to prevent degradation. For research purposes, it is critical to adhere to safety protocols and consult the MSDS for specific guidance.
Kaifeng Darui Pharmaceutical Co., Ltd.: A Trusted Supplier
Kaifeng Darui Pharmaceutical Co., Ltd., based in Henan, China, is a leading manufacturer of active pharmaceutical ingredients (APIs), including Aminopyrine. With a commitment to quality, innovation, and customer satisfaction, Darui has established itself as a reliable partner for pharmaceutical companies and research institutions worldwide. Key highlights of their operations include:
- Quality Assurance: Compliance with international standards such as ISO 9001 and in-house quality benchmarks.
- Packaging: Aminopyrine is packaged in 25 kg fiber drums or bags, ensuring safe transport and storage.
- Global Reach: Exporting to markets in Asia, Europe, and beyond, with a focus on meeting diverse client needs.
- Research Support: Providing high-purity Aminopyrine for proteomics research and analytical applications.
Darui’s dedication to sustainability and ethical manufacturing practices further enhances its reputation. By investing in eco-friendly production methods and maintaining transparency with clients, the company aligns with global demands for responsible pharmaceutical production.
Applications in Research and Industry
Beyond its historical medical uses, Aminopyrine is widely employed in scientific research. Its applications include:
- Proteomics Research: Used as a biochemical reagent for studying protein interactions and enzyme inhibition, particularly monoamine oxidase (MAO).
- Analytical Chemistry: Serves as a reference standard for high-performance liquid chromatography (HPLC) and other assays to quantify Aminopyrine and its metabolites.
- Organic Synthesis: Acts as a versatile reagent and catalyst in the synthesis of complex organic compounds.
- Chromogenic Agent: Utilized in assays to detect specific proteins due to its chromogenic properties.
Kaifeng Darui’s high-purity Aminopyrine is tailored for these applications, offering researchers reliable and consistent results. The company also provides certificates of analysis (COA) upon request, ensuring traceability and compliance with research standards.
Market Insights and Future Outlook
The global market for Aminopyrine is niche, primarily driven by research and industrial applications due to its restricted therapeutic use. However, demand persists in regions where regulatory frameworks allow its use in controlled settings. Kaifeng Darui is well-positioned to capitalize on this market, leveraging its expertise and infrastructure to meet growing needs in proteomics and analytical chemistry.
Emerging trends, such as the development of ultrasensitive immunochromatographic assays for detecting Aminopyrine in herbal teas, highlight the compound’s relevance in addressing fraud and ensuring product safety. Darui’s ability to supply high-quality Aminopyrine supports these advancements, contributing to public health and regulatory compliance.
Conclusion
Aminopyrine CAS 58-15-1 remains a significant compound in pharmaceutical and research contexts, despite its limited therapeutic use. Its chemical properties, coupled with Kaifeng Darui Pharmaceutical Co., Ltd.’s commitment to quality, make it a valuable resource for researchers and industry professionals. By adhering to stringent safety and quality standards, Darui ensures that its Aminopyrine meets the needs of a global market while addressing the compound’s complex regulatory landscape. For those seeking a reliable supplier, Kaifeng Darui stands out as a trusted partner, delivering excellence in every batch.
Call to Action
For more information about Aminopyrine CAS 58-15-1 or to request a quote, contact Kaifeng Darui Pharmaceutical Co., Ltd. today. Visit their website or reach out to their customer support team to explore how their high-quality APIs can support your research or industrial needs.
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