Antipyrine, also known as Phenazone, is a well-established pharmaceutical raw material with the Chemical Abstracts Service (CAS) number 60-80-0. Renowned for its analgesic, antipyretic, and anti-inflammatory properties, this compound has been a cornerstone in the pharmaceutical industry for over a century. Kaifeng Darui Pharmaceutical Co., Ltd., a leading manufacturer in China, is proud to produce high-quality Antipyrine, meeting stringent global standards for pharmaceutical applications. This article explores the properties, applications, manufacturing excellence, and unique advantages of Antipyrine CAS 60-80-0 as offered by Kaifeng Darui Pharmaceutical.
What is Antipyrine CAS 60-80-0?
Antipyrine, chemically known as 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one, is a pyrazolone derivative with the molecular formula C11H12N2O and a molar mass of 188.23 g/mol. It appears as a colorless crystal or white crystalline powder, is odorless, and has a slightly bitter taste. Antipyrine is highly soluble in water, ethanol, and chloroform, making it versatile for various pharmaceutical formulations. Its melting point ranges from 109°C to 111°C, and it has a density of approximately 1.14 g/cm³.
Historically, Antipyrine was one of the first synthetic drugs, introduced in the 1880s by a pupil of Emil Fischer in Germany. Its rapid adoption as an antipyretic and analgesic marked a significant milestone in pharmaceutical development. Today, Antipyrine remains relevant due to its efficacy in pain relief, fever reduction, and its role in testing drug-metabolizing enzymes in the liver.
Key Properties and Characteristics
Antipyrine’s physicochemical properties make it an ideal active pharmaceutical ingredient (API) for various applications. Here are its key characteristics:
- Analgesic Properties: Antipyrine effectively reduces pain, making it a key component in pain relief medications.
- Antipyretic Effects: It lowers fever, providing symptomatic relief in conditions like acute otitis media.
- Anti-inflammatory Action: As a non-steroidal anti-inflammatory drug (NSAID), it helps manage inflammation.
- Solubility: Soluble in water (1000 g/L at 20°C), ethanol, and chloroform, enabling its use in tablets, solutions, and ear drops.
- Stability: When stored properly, Antipyrine maintains its potency and effectiveness.
These properties, combined with its long-standing clinical use, ensure Antipyrine’s continued relevance in modern pharmacology.
Applications of Antipyrine
Antipyrine CAS 60-80-0 is a versatile API with applications across pharmaceutical and research domains. Its primary uses include:
1. Pain Relief and Fever Reduction
Antipyrine is widely used in formulations for pain relief and fever reduction. It is administered orally in tablet form or as ear drops, often in combination with benzocaine for enhanced local anesthetic effects. For example, Antipyrine and Benzocaine Otic Solution is a common treatment for ear pain associated with acute otitis media.
2. Pharmaceutical Research
Antipyrine serves as a reference standard in pharmacokinetic studies, particularly for assessing the activity of drug-metabolizing enzymes in the liver. Its predictable metabolism makes it an ideal marker for evaluating the effects of other drugs or diseases on hepatic function.
3. Analytical Reagent
In laboratory settings, Antipyrine is used as an analytical reagent for detecting nitric acid, nitrous acid, iodine, and elements forming complex cations. Its role in analytical chemistry underscores its versatility beyond therapeutic applications.
4. Veterinary Medicine
Antipyrine is also employed in veterinary medicine as an analgesic and antipyretic, demonstrating its broad applicability across species.
Kaifeng Darui Pharmaceutical Co., Ltd.: A Trusted Manufacturer
Kaifeng Darui Pharmaceutical Co., Ltd. is a prominent player in the Chinese pharmaceutical industry, specializing in the production of high-quality APIs and intermediates. With a commitment to excellence, the company adheres to strict quality control measures and complies with international standards such as USP, EP, BP, IP, and JP. Their Antipyrine CAS 60-80-0 is manufactured under current Good Manufacturing Practices (cGMP), ensuring purity, potency, and safety.
Located in Henan Province, Kaifeng Darui leverages advanced technology and rigorous quality assurance processes to deliver products that meet the needs of global pharmaceutical companies. Their state-of-the-art facilities and experienced team enable them to produce Antipyrine with consistent quality, making them a preferred supplier for pharmaceutical manufacturers worldwide.
Why Choose Antipyrine from Kaifeng Darui?
Kaifeng Darui Pharmaceutical stands out as a reliable source for Antipyrine CAS 60-80-0 due to several key advantages:
- High Purity: Their Antipyrine meets or exceeds industry standards, with a purity of ≥99%, ensuring optimal performance in pharmaceutical formulations.
- Competitive Pricing: Kaifeng Darui offers cost-effective solutions without compromising quality, making their Antipyrine accessible to a wide range of manufacturers.
- Global Compliance: The company adheres to international regulatory requirements, facilitating seamless integration into global supply chains.
- Reliable Supply Chain: With robust logistics and inventory management, Kaifeng Darui ensures timely delivery to meet customer demands.
- Customer Support: Their dedicated team provides technical assistance and after-sales service, fostering long-term partnerships with clients.
Manufacturing Process and Quality Control
The production of Antipyrine at Kaifeng Darui involves a meticulous process to ensure quality and consistency. The synthesis typically begins with the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with methyl iodide or dimethyl sulfate, followed by purification steps to achieve the desired purity. Key stages include:
- Synthesis: Controlled chemical reactions to form the Antipyrine molecule.
- Purification: Crystallization from ethanol/water or benzene to remove impurities.
- Testing: Comprehensive analysis using techniques like HPLC and gas chromatography to verify purity and composition.
- Packaging: Secure packaging to maintain stability during storage and transport.
Quality control is integral to Kaifeng Darui’s operations. Each batch undergoes rigorous testing for parameters such as melting point, solubility, and impurity levels, ensuring compliance with pharmacopeial standards.
Safety and Handling
While Antipyrine is generally safe for its intended uses, proper handling is essential to maintain its integrity and ensure user safety. Key considerations include:
- Storage: Store in a cool, dry place away from heat sources to prevent decomposition.
- Handling: Use appropriate personal protective equipment (PPE) to avoid inhalation or skin contact.
- Disposal: Follow local regulations for the disposal of chemical waste to minimize environmental impact.
Kaifeng Darui provides detailed Safety Data Sheets (SDS) with each shipment, outlining handling and safety guidelines.
Environmental and Regulatory Considerations
As an emerging pollutant, Antipyrine’s presence in the environment is a concern due to its persistence. Kaifeng Darui is committed to sustainable manufacturing practices, minimizing waste and ensuring proper treatment of byproducts. Their compliance with environmental regulations aligns with global efforts to reduce the ecological footprint of pharmaceutical production.
Additionally, Antipyrine is subject to regulatory oversight in various markets. Kaifeng Darui’s adherence to cGMP and pharmacopeial standards ensures that their product meets the requirements of regulatory bodies such as the FDA, EMA, and CFDA.
Future Prospects for Antipyrine
Despite the emergence of newer analgesics and antipyretics, Antipyrine remains relevant due to its efficacy and versatility. Ongoing research into its metabolites, such as 4-aminoantipyrine, may uncover new therapeutic applications. Additionally, its role in pharmacokinetic studies continues to drive demand in the research community.
Kaifeng Darui is poised to capitalize on these opportunities by investing in R&D and expanding their production capacity. Their focus on innovation and quality positions them as a leader in the global Antipyrine market.
Conclusion
Antipyrine CAS 60-80-0 is a time-tested pharmaceutical raw material with significant applications in pain relief, fever reduction, and research. Kaifeng Darui Pharmaceutical Co., Ltd. exemplifies excellence in its production, offering a high-purity, reliable product that meets the needs of pharmaceutical manufacturers worldwide. With a commitment to quality, compliance, and customer satisfaction, Kaifeng Darui is a trusted partner for those seeking premium Antipyrine. Whether for clinical, research, or veterinary applications, their Antipyrine stands as a testament to their expertise and dedication to advancing healthcare.
analgesic anti-inflammatory antipyretic Antipyrine API CAS 60-80-0 Kaifeng Darui Pharmaceutical pain relief Pharmaceutical raw material Phenazone
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