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In the realm of veterinary medicine, ensuring the health and welfare of livestock is paramount. Parasitic infections, particularly those caused by liver flukes and other helminths, pose significant challenges to animal health, leading to reduced productivity, malnutrition, and even mortality. Niclofolan, identified by its Chemical Abstracts Service (CAS) number 10331-57-4, is a highly effective anthelmintic agent that has become a cornerstone in combating these parasitic threats. Produced by Kaifeng Darui Pharmaceutical Co., Ltd., a reputable manufacturer in the pharmaceutical industry, Niclofolan is a trusted solution for veterinarians and livestock farmers worldwide. This article delves into the properties, applications, benefits, and production of Niclofolan, highlighting why Kaifeng Darui Pharmaceutical is a leader in this field.
What is Niclofolan CAS 10331-57-4?
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Niclofolan, also known as Nitroclofene, is a biphenyl anthelmintic compound primarily used in veterinary medicine to treat parasitic infections in domestic animals such as sheep, cattle, and pigs. Its chemical formula is C12H6Cl2N2O6, and it is characterized as a yellow crystalline powder with a melting point of 176–181°C. Niclofolan is soluble in acetone, chloroform, dimethylformamide, and sodium hydroxide solutions but insoluble in water, making it suitable for specific formulations like oral tablets or injectables.
The compound works by disrupting the energy metabolism of parasites, specifically by inhibiting succinate dehydrogenase, an enzyme critical to their survival. This action immobilizes and eventually kills a wide range of intestinal and tissue-dwelling parasites, including roundworms, tapeworms, and flukes, such as Fasciola hepatica (liver fluke). Its high safety margin and low toxicity make it a preferred choice for treating parasitic infections, particularly in livestock.
Applications of Niclofolan in Veterinary Medicine
Niclofolan is widely used to control and prevent parasitic infections that affect livestock health and productivity. Its primary application is in the treatment of fascioliasis, a condition caused by liver flukes, which is particularly prevalent in sheep and cattle. By eliminating parasites like Fasciola hepatica and Fasciola gigantica, Niclofolan helps restore normal liver function, improve nutrient absorption, and enhance overall animal welfare. Studies have shown that Niclofolan therapy can eliminate parasite eggs from feces, normalize eosinophil counts, and restore liver enzyme levels, indicating successful eradication of biliary flukes.
Beyond fascioliasis, Niclofolan is effective against other parasitic infections, including those caused by Clonorchis sinensis and paragonimiasis. Its versatility makes it a valuable tool in regions where parasitic diseases are endemic, particularly in grazing areas with high moisture levels that favor fluke development. The compound is typically administered orally or via injection, ensuring effective delivery while minimizing adverse effects.
Why Choose Niclofolan from Kaifeng Darui Pharmaceutical Co., Ltd.?
Kaifeng Darui Pharmaceutical Co., Ltd. is a leading manufacturer and supplier of veterinary pharmaceuticals in China, known for its commitment to quality, innovation, and competitive pricing. The company’s production of Niclofolan CAS 10331-57-4 adheres to strict international standards, ensuring that the product meets the needs of veterinarians and livestock farmers globally. Here are some reasons why Kaifeng Darui’s Niclofolan stands out:
- High Purity and Stability: Kaifeng Darui employs advanced manufacturing processes to produce Niclofolan with high purity and stability, ensuring consistent performance under normal storage conditions. The compound’s stability is maintained by avoiding exposure to electrostatic discharge, heat, and humidity.
- Regulatory Compliance: The company adheres to internationally recognized standards, such as ISO/IEC 17025, for the production of pharmaceutical reference materials. This ensures that Niclofolan meets regulatory requirements in various countries, although additional documentation may be required due to its controlled status in some regions.
- Competitive Pricing: Kaifeng Darui offers Niclofolan at competitive prices, making it accessible to a wide range of customers without compromising on quality. Their efficient production and supply chain management contribute to cost-effectiveness.
- Comprehensive Support: The company provides excellent after-sales service, including technical support and guidance on product use, ensuring that customers can maximize the benefits of Niclofolan in their veterinary practices.
Benefits of Using Niclofolan in Livestock Management
The use of Niclofolan in livestock management offers numerous benefits, making it an essential tool for farmers and veterinarians:
- Improved Animal Health: By eliminating parasitic infections, Niclofolan enhances livestock health, reducing symptoms such as anemia, weight loss, and organ damage caused by parasites.
- Increased Productivity: Healthy animals are more productive, leading to higher yields of milk, meat, and wool. Niclofolan helps farmers maintain robust livestock populations, contributing to economic gains.
- Cost-Effective Treatment: The high efficacy and low toxicity of Niclofolan mean that fewer treatments are needed, reducing overall costs for farmers. Its targeted action minimizes the need for broad-spectrum drugs that may have more side effects.
- Environmental Safety: When used according to guidelines, Niclofolan has a favorable environmental profile, with strict regulations ensuring minimal impact on ecosystems. However, proper disposal and handling are essential to avoid potential hazards.
Challenges and Considerations
While Niclofolan is highly effective, its use is subject to strict regulations in many countries due to potential environmental and human health concerns. Overuse or improper administration can lead to resistance in parasite populations, reducing the drug’s long-term efficacy. Additionally, there have been rare reports of intoxication when Niclofolan is used to treat certain parasitic infections in humans, underscoring the need for veterinary supervision and adherence to dosage guidelines.
Kaifeng Darui Pharmaceutical addresses these challenges by providing detailed product documentation and support to ensure safe and effective use. Customers are advised to consult with veterinarians and comply with local regulations when incorporating Niclofolan into their livestock management practices.
Conclusion
Niclofolan CAS 10331-57-4, produced by Kaifeng Darui Pharmaceutical Co., Ltd., is a powerful and reliable anthelmintic agent that plays a critical role in veterinary medicine. Its ability to combat a wide range of parasitic infections, coupled with its high safety margin and low toxicity, makes it a preferred choice for treating conditions like fascioliasis in livestock. Kaifeng Darui’s commitment to quality, regulatory compliance, and customer support further enhances the value of their Niclofolan product, positioning the company as a trusted partner in animal health.
For livestock farmers and veterinarians seeking an effective solution to parasitic infections, Niclofolan from Kaifeng Darui Pharmaceutical offers unparalleled benefits. By investing in this high-quality product, stakeholders can improve animal welfare, boost productivity, and contribute to sustainable livestock management. To learn more about Niclofolan or to place an order, contact Kaifeng Darui Pharmaceutical Co., Ltd. today.
animal welfare CAS 10331-57-4 Fasciola hepatica Kaifeng Darui Pharmaceutical livestock health Niclofolan Nitroclofene parasitic infections sheep liver fluke veterinary anthelmintic
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